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- The most common side effect associated with diuretics is potassium loss. With the exception of potassium-sparing versions, all diuretics may cause a loss of potassium in patients. Rarely, potassium-sparing diuretics can cause a build-up of potassium in the body. Patients should contact their physician if they have any of the following side effects from diuretics, most of which are related to diuresis (urinating too much) and dehydration:
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